Dr Pablo Cirino and CRT™ Hair Microinfusion

The Advanced Regenerative Hair Loss Treatment Changing How Medications Reach the Hair Follicle

When discussing innovation in hair restoration, the conversation often centres around new medications or surgical techniques. Yet one of the most exciting developments is not necessarily what is being delivered to the hair follicle, but how it gets there.

Developed by Brazilian physician and researcher Dr Pablo Cirino MD PhD, CRT™ (Cirino Regenerative Technique) is an advanced hair microinfusion protocol designed to enhance the delivery of proven hair growth medications directly to the follicle while simultaneously stimulating the scalp’s own regenerative pathways. As part of The Hair Loss Lab Podcast, SpexHair travelled to Paris to sit down with Dr Pablo Cirino and explore the science, research and philosophy behind CRT™, a technique that is now influencing regenerative hair restoration protocols worldwide.

What is CRT™ (Cirino Regenerative Technique)?

CRT™ is a minimally invasive hair restoration treatment developed by Dr Pablo Cirino after years of clinical research into scalp regeneration and targeted follicular therapy. Unlike conventional topical treatments that must first penetrate the skin barrier, CRT™ uses precision microinfusion technology to create controlled microchannels within the scalp. These channels allow customised therapeutic compounds to be delivered directly to the level of the hair follicle, where they can potentially achieve greater biological activity.The technique combines three key principles:

• Controlled scalp microstimulation
• Targeted follicular medication delivery
• Activation of natural regenerative signalling pathways

Today, Dr Pablo Cirino’s CRT™ protocol has inspired a number of clinic-specific treatment systems around the world, making him one of the pioneers of modern hair microinfusion therapy.

Why Targeted Delivery Matters

Many hair loss medications are clinically proven, yet their effectiveness can be limited by the scalp’s natural protective barrier. Traditional topical products may never reach optimal concentrations around the dermal papilla, the structure responsible for controlling hair growth. CRT™ was designed to overcome this challenge by improving local delivery while reducing unnecessary systemic exposure.

This precision approach aims to:

• Improve medication penetration
• Enhance follicular stimulation
• Increase treatment consistency
• Support stronger regenerative signalling

Rather than replacing established medical therapies, CRT™ seeks to maximise their potential through intelligent delivery.

How Does Dr Pablo Cirino’s CRT™ Treatment Work?

CRT™ operates through two complementary mechanisms.

1. Mechanical Regenerative Stimulation

Thousands of microscopic channels are created across thinning areas of the scalp using a specialised precision device.

This controlled stimulation activates the body’s natural healing response, encouraging the release of growth factors and vascular signalling molecules associated with follicular repair and improved scalp circulation.

2. Precision Follicular Microinfusion

Immediately after microchannel creation, customised therapeutic compounds are infused directly into the treatment zone.

Depending on the individual patient and physician protocol, these may include:

• Low-dose minoxidil
• Dutasteride
• Peptides such as GHK-Cu
• Micronutrients
• Platelet Rich Plasma (PRP)
• Regenerative biologics where clinically appropriate

By placing active ingredients closer to the follicle, CRT™ aims to create a more efficient therapeutic environment than topical application alone.

Who is a Candidate for CRT™ Hair Microinfusion?

According to Dr Pablo Cirino’s treatment philosophy, CRT™ may be suitable for:

• Men experiencing early to moderate androgenetic alopecia
• Women with female pattern hair loss
• Patients whose progress has plateaued on medication alone
• Hair transplant patients seeking to maintain or optimise results
• Individuals looking for a non-surgical regenerative treatment

A comprehensive medical assessment remains essential, as every hair loss diagnosis requires an individualised treatment strategy.

What Happens During a CRT™ Session?

A typical treatment takes approximately 25 to 30 minutes and is performed entirely in a clinical setting.

The procedure generally includes:

• Scalp cleansing and preparation
• Local anaesthetic for comfort
• Controlled microinfusion of treatment areas
• Minimal recovery time

Most patients return to normal activities the same day, with only mild redness or temporary scalp sensitivity.

When Can Patients Expect Results?

Hair restoration is a gradual biological process rather than an overnight transformation.

Most CRT™ treatment protocols consist of a series of monthly sessions, with many patients beginning to notice measurable improvements in hair quality and density after approximately three months and visible cosmetic changes developing between four and six months. Maintenance treatments may then form part of a long-term hair preservation strategy.

SpexHair Perspective

After speaking with thousands of patients over more than two decades, one principle remains consistent. There is rarely a single treatment that changes everything. Long-term success comes from accurate diagnosis, realistic expectations and combining evidence-based therapies into a personalised strategy. What makes Dr Pablo Cirino’s CRT™ technique particularly interesting is that it focuses on enhancing the effectiveness of proven treatments rather than chasing the latest miracle cure. By improving how medications reach the follicle while stimulating the scalp’s own regenerative response, CRT™ represents a thoughtful evolution in non-surgical hair restoration. That is precisely why we wanted to sit down with Dr Pablo Cirino for The Hair Loss Lab Podcast and explore the science behind one of the most talked about regenerative hair loss treatments currently emerging in the field.

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